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diff --git a/academic/prank-msa/README b/academic/prank-msa/README new file mode 100644 index 000000000000..4bc1a9f838f1 --- /dev/null +++ b/academic/prank-msa/README @@ -0,0 +1,32 @@ +PRANK: Probabilistic Alignment Kit + +PRANK is a probabilistic multiple alignment program for DNA, codon and +amino-acid sequences. It is based on a novel algorithm that treats +insertions correctly and avoids over-estimation of the number of +deletion events. + +In addition, PRANK borrows ideas from maximum likelihood (ML) methods +used in phylogenetics and correctly takes into account the evolutionary +distances between sequences. + +Lastly, PRANK allows for defining a potential structure for sequences to +be aligned and then, simultaneously with the alignment, predicts the +locations of structural units in the sequences. + +NOTE! +The dependencies listed in the REQUIRED field are not needed for +building PRANK. They are, however, highly recommended for the complete +functionality of the program: + +1) Progressive alignment requires a guide tree. If no tree is provided, +PRANK constructs one by calling MAFFT to make a quick alignment and +infers an NJ tree from the evolutionary distances based on that. + +2) The standard PRANK algorithm is based on an exhaustive search of the +best pairwise solution. PRANK uses Exonerate to anchor the pairwise +alignments and thus speed up the process. + +3) To improve the ancestral reconstruction, PRANK uses BppAncestor from +the BppSuite. + +NOTE 2: This will not build on a 32bit system. |