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diff --git a/academic/cistrome-MACS/README b/academic/cistrome-MACS/README new file mode 100644 index 0000000000000..d039cfacfd6e6 --- /dev/null +++ b/academic/cistrome-MACS/README @@ -0,0 +1,16 @@ +MACS: Model-based Analysis of ChIP-Seq + +Next generation parallel sequencing technologies made chromatin +immunoprecipitation followed by sequencing (ChIP-Seq) a popular +strategy to study genome-wide protein-DNA interactions, while creating +challenges for analysis algorithms. We present Model-based Analysis of +ChIP-Seq (MACS) on short reads sequencers such as Genome Analyzer +(Illumina / Solexa). MACS empirically models the length of the +sequenced ChIP fragments, which tends to be shorter than sonication or +library construction size estimates, and uses it to improve the +spatial resolution of predicted binding sites. MACS also uses a +dynamic Poisson distribution to effectively capture local biases in +the genome sequence, allowing for more sensitive and robust +prediction. MACS compares favorably to existing ChIP-Seq peak-finding +algorithms, is publicly available open source, and can be used for +ChIP-Seq with or without control samples. |